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冠心病心绞痛中医证候的现代研究

冠心病心绞痛中医证候的现代研究

杨茗茜1,张哲2,袁东超1,吴瑾1,杨关林1

(1.辽宁中医药大学,沈阳;2.辽医院,沈阳)

[摘要]目的:探讨理化指标在冠心病(稳定型心绞痛)与不同中医证候间的相关性。方法:采用横断面调查方法,一次性采集12个分中心符合入选标准的患者,运用t检验、卡方检验、二分类逐步logistic回归,探讨冠心病(稳定型心绞痛)与中医证候在理化检查指标方面的关系。结果:t检验及卡方检验结果显示半胱氨酸、血尿酸、空腹血糖、高密度脂蛋白、颈动脉彩超、心电图、心脏彩超与冠心病稳定型心绞痛中医病证间的关系均有统计学意义(P0.05)。二分类逐步logistic回归分析后,颈动脉彩超、心电图、心脏彩超均与各中医病证关系密切,并且甘油三酯与射血分数在疾病组中存在特异性,相对危险度(OR)分别为1.,0.,血尿酸与空腹血糖在痰瘀组中存在特异性,OR值分别为1.,1.,甘油三酯在气瘀组中存在特异性,OR值为1.。结论:临床理化指标在冠心病稳定型心绞痛与其不同中医证候之间存在相关性。

[关键词]冠心病;中医证候;理化检查指标;t检验;卡方检验;二分类逐步logistic回归

ModernresearchofTCMSyndromesofanginapectorisofcoronaryheartdisease

YANGMing-qian1,ZHANGZhe2,YUANDong-chao1,WUJin1,YANGGuan-lin1

(1.TheFirstClinicalCollege,LiaoningUniversityofTraditionalChineseMedicine(TCM),Shenyang,China;2.TheAffiliatedHospitalofLiaoningUniversityofTCM,Shenyang,China)

AbstractObjective:TheaimofthisstudywastoinvestigatetherelationshipbetweentraditionalChinesemedicine(TCM)Syndromeofstableanginapectorisandphysicalandchemicalexaminationofindicators.Method:Throughthemethodofcross-sectionalsurvey,casesofpatientsfrom12sub-centersthatmettheinclusioncriteriawerecollected,subjecttochi-squaretest,binarystepwiselogisticregressiontoexploretherelationshipbetweenTCMSyndromeofstableanginapectorisandphysicalandchemicalexaminationofindicators.Result:Correlationanalysisandchi-squaretestresultsshowedthattherelationshipbetweencysteine,uricacid,fastingglucose,triglycerides,highdensitylipoprotein,ejectionfraction,activatedpartialthromboplastintime,C-reactiveprotein,carotidultrasound,electrocardiogram(ECG),echocardiographyandTCMsyndromeofstableanginapectorisweresignificantlyrelated(P0.05).Binarystepwiselogisticregressionanalysisshowedthatcarotidultrasound,ECG,echocardiographywerecloselyrelatedtoeachTCMSyndrome.Andtriglyceridesandejectionfractionwerespecificinthediseasegroup,withtheoddsratio(OR)valuesof1.and0..Theblooduricacidandfastingglucosewerespecificinphlegmandbloodstasisgroup,withtheORvaluesof1.and1..Triglycerideswerespecificinthegasandbloodstasisgroup,withaORvalueof1..Conclusion:ThereisarelationshipbetweentheTCMSyndromeofstableanginapectorisandthephysicalandchemicalexaminationindexcorrelated,whichisinlinewithclinicalpractice.

Keywords:physicalandchemicalinspection;coronaryheartdisease;correlationanalysis;chi-squaretest;binarystepwiselogisticregression

冠心病,因冠状动脉硬化或冠状动脉功能性改变(痉挛)导致的血管腔狭窄堵塞或心肌缺氧坏死而引起的心脏疾病,亦称冠状动脉粥样硬化性心脏病或缺血性心脏病[1]。由于冠心病对人类的危害日益显著,故各国开展了大量系统的有关冠心病治疗的研究,使冠心病成为近10年心血管病治疗学领域中进展最快的疾病之一[2]。许多流行病学和临床研究结果表明多项理化检查指标与冠心病稳定型心绞痛相关,空腹血糖[6-9]、血尿酸[10-11]、C反应蛋白[12-13]等多个因素是冠心病的重要危险因素,能够为冠心病的诊断提供相关证据。在冠心病西医诊疗规模化的基础上,冠心病的中医辨证施治引起人们广泛







































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